Table of Contents
PREFACE ix
CONTRIBUTORS xi
1 TOXICOLOGY, "OMICS" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER 1 Darrell R. Boverhof and B. Bhaskar Gollapudi
2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT 13 Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, and Lynne T. Haber
3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH FORWARD 41 Darrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and Heli Hollnagel
4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA 65 Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, and Leming Shi
5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS 81 Jiri Aubrecht and Ebru Caba
6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS 99 Mark R. Fielden
7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY 117 Jorge M. Naciff and George P. Daston
8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING 147 M. Ann Mongan and Hisham K. Hamadeh
9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS 177 Cliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T. Smith
10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT 207 Daniel L. Villeneuve, Dalma Martinovi´c, and Gerald T. Ankley
11 ANALYSIS OF TRANSCRIPTOMIC DOSE–RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT 237 Russell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin E. Andersen
12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS, AND CHALLENGES 251 Alan Dombkowski and J. Craig Rowlands
13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES 267 Anne S. Kienhuis, Joost H. M. van Delft, and Jos C. S. Kleinjans
14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK 293 Kathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H. Benson
15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN 323 Ken-ichi Aisaki and Jun Kanno
16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION 331 Lois D. Lehman-McKeeman and William R. Foster
17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH 349 Sarah N. Campion and Kim Boekelheide
INDEX 357
